Cat avoiding all but one room in house after possible bug bite or sting

A few days ago my cat started twitching and running like crazy and panting, hiding under couch. Took to vet where he checked out fine, they gave him a shot of Benadryl. He has been in my bedroom and bathroom ever since. Went on prednisone Saturday and yesterday back to vet where he had another full exam, xrays, bloodwork and urinalysis. All was normal. If he comes out of room, it only lasts a

minute and he twitches and runs back in. He is perfectly happy and fine in there. Anyone have this experience and how do I get him comfortable in rest of house again? His brother is fine

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